منابع مشابه
New genes and new insights from old genes: update on Alzheimer disease.
PURPOSE OF REVIEW This article discusses the current status of knowledge regarding the genetic basis of Alzheimer disease (AD) with a focus on clinically relevant aspects. RECENT FINDINGS The genetic architecture of AD is complex, as it includes multiple susceptibility genes and likely nongenetic factors. Rare but highly penetrant autosomal dominant mutations explain a small minority of the c...
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Published work (D. J. McGeoch, Nucleic Acids Res. 18:4105-4110, 1990; J. E. McGeehan, N. W. Depledge, and D. J. McGeoch, Curr. Protein Peptide Sci. 2:325-333, 2001) has indicated that evolution of dUTPase in the class of herpesviruses that infect mammals and birds involved capture of a host gene followed by a duplication event that resulted in a coding region comprising two fused dUTPase domain...
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Many crucial components of signal transduction, developmental, and metabolic pathways have functionally redundant copies. Further, these redundancies show surprising evolutionary stability over prolonged time scales. We propose that redundancies are not just archeological leftovers of ancient gene duplications, but rather that synergy arising from feedback between redundant copies may serve as ...
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The evolution of novel features requires evolutionary change in gene function. New work in nematodes shows how conserved genes can nonetheless contribute to innovative traits.
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The vast differences between vertebrate and arthropod eyes suggest that the recently discovered homologous master control genes for eye development had another function before eyes evolved in the early Cambrian.
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ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/382124a0